藥物交互作用
Amphotericin b deoxycholate + Colistin
嚴重程度: 嚴重
Amphotericin b deoxycholate and Colistin: major interaction.
最後更新
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摘要
Both drugs are nephrotoxic, and using them together increases the chance of acute kidney injury. Colistin also carries neurotoxic effects, and renal impairment raises its exposure further.
用白話說明這項交互作用的意義
Amphotericin b deoxycholate and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive direct tubular toxicity and renal vasoconstriction.
處置方式
Avoid concurrent use if alternatives exist; otherwise monitor serum creatinine and electrolytes frequently, keep patients well hydrated and adjust colistin dose to renal function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Colistin 的其他交互作用
常見問題
Can I take Amphotericin b deoxycholate with Colistin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and using them together increases the chance of acute kidney injury. Colistin also carries neurotoxic effects, and renal impairment raises its exposure further.
How serious is the interaction between Amphotericin b deoxycholate and Colistin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if alternatives exist; otherwise monitor serum creatinine and electrolytes frequently, keep patients well hydrated and adjust colistin dose to renal function.
What other medicines interact with Colistin?
MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b. The full list is on the Colistin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
