藥物交互作用
Amphotericin b deoxycholate + Digoxin
嚴重程度: 嚴重
Amphotericin b deoxycholate and Digoxin: major interaction.
最後更新
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摘要
Amphotericin B commonly causes hypokalemia and hypomagnesemia, which sensitize the myocardium to digoxin. This increases the risk of digoxin toxicity and arrhythmias even at normal serum levels.
用白話說明這項交互作用的意義
Amphotericin b deoxycholate and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Amphotericin-induced renal potassium and magnesium wasting produces additive pharmacodynamic enhancement of digoxin toxicity.
處置方式
Monitor and correct serum potassium and magnesium regularly. Check digoxin levels and ECG, and consider a digoxin dose reduction if electrolyte disturbances persist.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Digoxin 的其他交互作用
常見問題
Can I take Amphotericin b deoxycholate with Digoxin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphotericin B commonly causes hypokalemia and hypomagnesemia, which sensitize the myocardium to digoxin. This increases the risk of digoxin toxicity and arrhythmias even at normal serum levels.
How serious is the interaction between Amphotericin b deoxycholate and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor and correct serum potassium and magnesium regularly. Check digoxin levels and ECG, and consider a digoxin dose reduction if electrolyte disturbances persist.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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