藥物交互作用
Amlodipine-hydrochlorothiazide-valsartan + Digoxin
嚴重程度: 嚴重
Amlodipine-hydrochlorothiazide-valsartan and Digoxin: major interaction.
最後更新
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摘要
Hydrochlorothiazide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and the risk of arrhythmias. Valsartan-related renal changes may also modestly raise digoxin levels.
用白話說明這項交互作用的意義
Amlodipine-hydrochlorothiazide-valsartan and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
為什麼會發生
Diuretic-induced hypokalemia and hypomagnesemia enhance digoxin toxicity, with possible reduced renal digoxin clearance.
處置方式
Monitor potassium, magnesium and renal function regularly and keep potassium in the normal range. Check digoxin levels and watch for toxicity symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amlodipine-hydrochlorothiazide-valsartan 的其他交互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan 禁忌併用
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 嚴重
Digoxin 的其他交互作用
常見問題
Can I take Amlodipine-hydrochlorothiazide-valsartan with Digoxin?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hydrochlorothiazide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and the risk of arrhythmias. Valsartan-related renal changes may also modestly raise digoxin levels.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium and renal function regularly and keep potassium in the normal range. Check digoxin levels and watch for toxicity symptoms.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
