藥物交互作用
Anastrozole + Bazedoxifene / conjugated estrogens
嚴重程度: 禁忌併用
Anastrozole and Bazedoxifene / conjugated estrogens: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Anastrozole lowers estrogen levels in postmenopausal women with hormone receptor-positive breast cancer, whereas conjugated estrogens supply estrogen. The therapy opposes the intended anti-estrogen effect and may reduce cancer control.
用白話說明這項交互作用的意義
Anastrozole and Bazedoxifene / conjugated estrogens are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Pharmacodynamic antagonism: exogenous estrogen counteracts aromatase inhibition.
處置方式
Do not combine. Use non-hormonal options for vasomotor symptoms in patients on anastrozole.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Anastrozole 的其他交互作用
常見問題
Can I take Anastrozole with Bazedoxifene / conjugated estrogens?
MediHelp rates the interaction as contraindicated. Anastrozole and Bazedoxifene / conjugated estrogens are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Anastrozole lowers estrogen levels in postmenopausal women with hormone receptor-positive breast cancer, whereas conjugated estrogens supply estrogen. The therapy opposes the intended anti-estrogen effect and may reduce cancer control.
How serious is the interaction between Anastrozole and Bazedoxifene / conjugated estrogens?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use non-hormonal options for vasomotor symptoms in patients on anastrozole.
What other medicines interact with Anastrozole?
MediHelp also lists interactions of Anastrozole with, for example, Bazedoxifene-conjugated estrogens, Conjugated estrogens, Estradiol. The full list is on the Anastrozole page.
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