藥物交互作用
Antithrombin alfa + Ethinyl estradiol-levonorgestrel
嚴重程度: 嚴重
Antithrombin alfa and Ethinyl estradiol-levonorgestrel: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Combined hormonal contraceptives increase thrombotic risk, which opposes the intended antithrombotic effect of antithrombin. In patients with antithrombin deficiency, estrogen-containing products add substantially to thrombosis risk.
用白話說明這項交互作用的意義
Antithrombin alfa and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Estrogen raises procoagulant factors and lowers antithrombin and protein S activity, pharmacodynamically opposing antithrombin replacement.
處置方式
Avoid estrogen-containing contraceptives in patients with antithrombin deficiency; use a progestin-only or non-hormonal method. Monitor antithrombin activity and coagulation status.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ethinyl estradiol-levonorgestrel 的其他交互作用
- Ethinyl estradiol-levonorgestrel + Fezolinetant 禁忌併用
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir 禁忌併用
- Ethinyl estradiol-levonorgestrel + Tranexamic acid 禁忌併用
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel 嚴重
- Amobarbital + Ethinyl estradiol-levonorgestrel 嚴重
- Anastrozole + Ethinyl estradiol-levonorgestrel 嚴重
常見問題
Can I take Antithrombin alfa with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as major. Antithrombin alfa and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combined hormonal contraceptives increase thrombotic risk, which opposes the intended antithrombotic effect of antithrombin. In patients with antithrombin deficiency, estrogen-containing products add substantially to thrombosis risk.
How serious is the interaction between Antithrombin alfa and Ethinyl estradiol-levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen-containing contraceptives in patients with antithrombin deficiency; use a progestin-only or non-hormonal method. Monitor antithrombin activity and coagulation status.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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