藥物交互作用
Ethinyl estradiol-levonorgestrel + Tranexamic acid
嚴重程度: 禁忌併用
Ethinyl estradiol-levonorgestrel and Tranexamic acid: contraindicated interaction.
最後更新
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摘要
Combined hormonal contraceptives raise the risk of venous thromboembolism and tranexamic acid is antifibrinolytic, so together the thrombotic risk is increased. Oral tranexamic acid labeling contraindicates its use with combined hormonal contraception.
用白話說明這項交互作用的意義
Ethinyl estradiol-levonorgestrel and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Tranexamic acid belongs to Cardiovascular.
為什麼會發生
Additive prothrombotic effects from estrogen-induced coagulation changes and antifibrinolysis.
處置方式
Avoid coadministration; for heavy menstrual bleeding consider a non-hormonal or progestin-only alternative, or an alternative to tranexamic acid.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ethinyl estradiol-levonorgestrel 的其他交互作用
- Ethinyl estradiol-levonorgestrel + Fezolinetant 禁忌併用
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir 禁忌併用
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel 嚴重
- Amobarbital + Ethinyl estradiol-levonorgestrel 嚴重
- Anastrozole + Ethinyl estradiol-levonorgestrel 嚴重
- Antithrombin alfa + Ethinyl estradiol-levonorgestrel 嚴重
Tranexamic acid 的其他交互作用
常見問題
Can I take Ethinyl estradiol-levonorgestrel with Tranexamic acid?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-levonorgestrel and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combined hormonal contraceptives raise the risk of venous thromboembolism and tranexamic acid is antifibrinolytic, so together the thrombotic risk is increased. Oral tranexamic acid labeling contraindicates its use with combined hormonal contraception.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Tranexamic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; for heavy menstrual bleeding consider a non-hormonal or progestin-only alternative, or an alternative to tranexamic acid.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Aminocaproic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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