藥物交互作用
Antithrombin alfa + Piperacillin-tazobactam
嚴重程度: 中度
Antithrombin alfa and Piperacillin-tazobactam: moderate interaction.
最後更新
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摘要
Piperacillin can impair platelet function and, at high doses, may contribute to bleeding. Antithrombin enhances heparin-mediated anticoagulation, so bleeding risk could be additive. The clinical significance is uncertain and likely modest.
用白話說明這項交互作用的意義
Antithrombin alfa and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Additive effects on hemostasis: penicillin-induced platelet dysfunction combined with enhanced antithrombin-mediated anticoagulation.
處置方式
Monitor for bleeding and coagulation parameters such as aPTT or anti-Xa when used with heparin. Adjust anticoagulant dosing as clinically indicated.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Piperacillin-tazobactam 的其他交互作用
常見問題
Can I take Antithrombin alfa with Piperacillin-tazobactam?
MediHelp rates the interaction as moderate. Antithrombin alfa and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piperacillin can impair platelet function and, at high doses, may contribute to bleeding. Antithrombin enhances heparin-mediated anticoagulation, so bleeding risk could be additive. The clinical significance is uncertain and likely modest.
How serious is the interaction between Antithrombin alfa and Piperacillin-tazobactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters such as aPTT or anti-Xa when used with heparin. Adjust anticoagulant dosing as clinically indicated.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin iii. The full list is on the Piperacillin-tazobactam page.
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