藥物交互作用
Apalutamide + Norethisterone
嚴重程度: 嚴重
Apalutamide and Norethisterone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Apalutamide may substantially reduce norethisterone exposure. Hormonal contraception may fail, and bleeding irregularities may occur.
用白話說明這項交互作用的意義
Apalutamide and Norethisterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Norethisterone belongs to Endocrine.
為什麼會發生
Apalutamide induces CYP3A4, increasing norethisterone metabolism.
處置方式
Use an alternative non-hormonal contraceptive method during and after apalutamide treatment. Monitor for loss of effect if norethisterone is used therapeutically.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Norethisterone 的其他交互作用
Apalutamide 的其他交互作用
常見問題
Can I take Apalutamide with Norethisterone?
MediHelp rates the interaction as major. Apalutamide and Norethisterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may substantially reduce norethisterone exposure. Hormonal contraception may fail, and bleeding irregularities may occur.
How serious is the interaction between Apalutamide and Norethisterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative non-hormonal contraceptive method during and after apalutamide treatment. Monitor for loss of effect if norethisterone is used therapeutically.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Belzutifan. The full list is on the Norethisterone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
