藥物交互作用
Apalutamide + Cobicistat
嚴重程度: 禁忌併用
Apalutamide and Cobicistat: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Apalutamide may markedly lower cobicistat levels, reducing its pharmacokinetic boosting of coadministered antiretrovirals. This risks subtherapeutic antiviral concentrations, virologic failure and resistance.
用白話說明這項交互作用的意義
Apalutamide and Cobicistat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Cobicistat belongs to Miscellaneous.
為什麼會發生
Induction of CYP3A4 increases cobicistat clearance.
處置方式
Avoid the combination and use a non-boosted antiretroviral regimen or an alternative antiandrogen. Seek HIV specialist advice if coadministration is considered.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Apalutamide 的其他交互作用
Cobicistat 的其他交互作用
常見問題
Can I take Apalutamide with Cobicistat?
MediHelp rates the interaction as contraindicated. Apalutamide and Cobicistat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide may markedly lower cobicistat levels, reducing its pharmacokinetic boosting of coadministered antiretrovirals. This risks subtherapeutic antiviral concentrations, virologic failure and resistance.
How serious is the interaction between Apalutamide and Cobicistat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-boosted antiretroviral regimen or an alternative antiandrogen. Seek HIV specialist advice if coadministration is considered.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Doravirine, Elbasvir / grazoprevir. The full list is on the Apalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
