藥物交互作用
Apalutamide + Doravirine
嚴重程度: 禁忌併用
Apalutamide and Doravirine: contraindicated interaction.
最後更新
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摘要
Apalutamide is a strong CYP3A inducer and can markedly lower doravirine plasma concentrations. This may lead to loss of virologic suppression and selection of HIV resistance.
用白話說明這項交互作用的意義
Apalutamide and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Doravirine belongs to Anti Virals.
為什麼會發生
Apalutamide induces CYP3A4, increasing the metabolism of doravirine, which is a CYP3A substrate.
處置方式
Do not coadminister; choose an alternative antiandrogen or antiretroviral regimen without dependence on CYP3A exposure. Allow time for enzyme induction to wane after stopping apalutamide before relying on doravirine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Apalutamide 的其他交互作用
Doravirine 的其他交互作用
常見問題
Can I take Apalutamide with Doravirine?
MediHelp rates the interaction as contraindicated. Apalutamide and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide is a strong CYP3A inducer and can markedly lower doravirine plasma concentrations. This may lead to loss of virologic suppression and selection of HIV resistance.
How serious is the interaction between Apalutamide and Doravirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose an alternative antiandrogen or antiretroviral regimen without dependence on CYP3A exposure. Allow time for enzyme induction to wane after stopping apalutamide before relying on doravirine.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Elbasvir / grazoprevir. The full list is on the Apalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
