藥物交互作用
Apixaban + Ketorolac
嚴重程度: 禁忌併用
Apixaban and Ketorolac: contraindicated interaction.
最後更新
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摘要
Ketorolac inhibits platelet function and damages the gastric mucosa, which adds to the bleeding risk of apixaban. Serious gastrointestinal and other hemorrhages may result. Ketorolac labeling contraindicates its use with anticoagulants at therapeutic doses.
用白話說明這項交互作用的意義
Apixaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apixaban belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
為什麼會發生
Additive hemostatic impairment: NSAID antiplatelet effect and mucosal injury combined with factor Xa inhibition.
處置方式
Avoid the combination and use a non-NSAID analgesic such as paracetamol. If an NSAID is absolutely needed, choose a different agent at the lowest dose with gastroprotection and bleeding monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ketorolac 的其他交互作用
Apixaban 的其他交互作用
常見問題
Can I take Apixaban with Ketorolac?
MediHelp rates the interaction as contraindicated. Apixaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac inhibits platelet function and damages the gastric mucosa, which adds to the bleeding risk of apixaban. Serious gastrointestinal and other hemorrhages may result. Ketorolac labeling contraindicates its use with anticoagulants at therapeutic doses.
How serious is the interaction between Apixaban and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-NSAID analgesic such as paracetamol. If an NSAID is absolutely needed, choose a different agent at the lowest dose with gastroprotection and bleeding monitoring.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
