藥物交互作用
Apixaban + Defibrotide
嚴重程度: 禁忌併用
Apixaban and Defibrotide: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Defibrotide has antithrombotic and profibrinolytic effects, so adding apixaban increases the risk of serious bleeding. Defibrotide labeling contraindicates concurrent systemic anticoagulants.
用白話說明這項交互作用的意義
Apixaban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apixaban belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.
為什麼會發生
Additive pharmacodynamic effects on hemostasis from factor Xa inhibition plus enhanced fibrinolysis.
處置方式
Do not co-administer; interrupt apixaban during defibrotide therapy under specialist guidance. Central line maintenance is the usual exception.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Apixaban 的其他交互作用
Defibrotide 的其他交互作用
常見問題
Can I take Apixaban with Defibrotide?
MediHelp rates the interaction as contraindicated. Apixaban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has antithrombotic and profibrinolytic effects, so adding apixaban increases the risk of serious bleeding. Defibrotide labeling contraindicates concurrent systemic anticoagulants.
How serious is the interaction between Apixaban and Defibrotide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; interrupt apixaban during defibrotide therapy under specialist guidance. Central line maintenance is the usual exception.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Edoxaban, Ketorolac. The full list is on the Apixaban page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
