藥物交互作用
Argatroban + Ketorolac
嚴重程度: 禁忌併用
Argatroban and Ketorolac: contraindicated interaction.
最後更新
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摘要
Ketorolac inhibits platelet function and can cause gastrointestinal ulceration, while argatroban is a direct thrombin inhibitor, so bleeding risk is substantially increased. Ketorolac labeling contraindicates its use in patients at risk of bleeding and with concurrent anticoagulants.
用白話說明這項交互作用的意義
Argatroban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Argatroban belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
為什麼會發生
Additive hemostatic impairment from NSAID-mediated platelet inhibition and direct thrombin inhibition.
處置方式
Avoid ketorolac in patients receiving argatroban and use a non-NSAID analgesic such as paracetamol or an appropriate alternative; monitor for bleeding if exposure has occurred.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ketorolac 的其他交互作用
Argatroban 的其他交互作用
常見問題
Can I take Argatroban with Ketorolac?
MediHelp rates the interaction as contraindicated. Argatroban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac inhibits platelet function and can cause gastrointestinal ulceration, while argatroban is a direct thrombin inhibitor, so bleeding risk is substantially increased. Ketorolac labeling contraindicates its use in patients at risk of bleeding and with concurrent anticoagulants.
How serious is the interaction between Argatroban and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients receiving argatroban and use a non-NSAID analgesic such as paracetamol or an appropriate alternative; monitor for bleeding if exposure has occurred.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
