藥物交互作用
Apomorphine + Metoclopramide
嚴重程度: 嚴重
Apomorphine and Metoclopramide: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Metoclopramide blocks the dopamine receptors that apomorphine stimulates, reducing apomorphine's effect in Parkinson disease. Parkinsonian symptoms may worsen.
用白話說明這項交互作用的意義
Apomorphine and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apomorphine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
為什麼會發生
Pharmacodynamic antagonism at central D2 receptors.
處置方式
Avoid metoclopramide. Use domperidone where available, or ondansetron, for nausea with apomorphine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Metoclopramide 的其他交互作用
Apomorphine 的其他交互作用
常見問題
Can I take Apomorphine with Metoclopramide?
MediHelp rates the interaction as major. Apomorphine and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide blocks the dopamine receptors that apomorphine stimulates, reducing apomorphine's effect in Parkinson disease. Parkinsonian symptoms may worsen.
How serious is the interaction between Apomorphine and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metoclopramide. Use domperidone where available, or ondansetron, for nausea with apomorphine.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
