藥物交互作用
Aripiprazole + Metoclopramide
嚴重程度: 嚴重
Aripiprazole and Metoclopramide: major interaction.
最後更新
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摘要
Both drugs block dopamine D2 receptors, so combined use increases the risk of extrapyramidal symptoms, tardive dyskinesia and rarely neuroleptic malignant syndrome. Aripiprazole is a partial agonist, but the risk remains.
用白話說明這項交互作用的意義
Aripiprazole and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
為什麼會發生
Additive central dopamine D2 receptor antagonism.
處置方式
Avoid combining where possible and choose an antiemetic without central dopamine antagonism, such as ondansetron. If unavoidable, use the shortest course and monitor for movement disorders and fever with rigidity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Metoclopramide 的其他交互作用
Aripiprazole 的其他交互作用
常見問題
Can I take Aripiprazole with Metoclopramide?
MediHelp rates the interaction as major. Aripiprazole and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs block dopamine D2 receptors, so combined use increases the risk of extrapyramidal symptoms, tardive dyskinesia and rarely neuroleptic malignant syndrome. Aripiprazole is a partial agonist, but the risk remains.
How serious is the interaction between Aripiprazole and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and choose an antiemetic without central dopamine antagonism, such as ondansetron. If unavoidable, use the shortest course and monitor for movement disorders and fever with rigidity.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
