藥物交互作用
Aprepitant + Nirogacestat
嚴重程度: 嚴重
Aprepitant and Nirogacestat: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Aprepitant may increase nirogacestat exposure by inhibiting CYP3A4. This could worsen adverse effects such as diarrhea, ovarian toxicity, hepatotoxicity and electrolyte disturbances.
用白話說明這項交互作用的意義
Aprepitant and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Nirogacestat belongs to Oncology.
為什麼會發生
Aprepitant inhibits CYP3A4, the main metabolic pathway of nirogacestat.
處置方式
Avoid moderate CYP3A inhibitors and use an alternative antiemetic. If unavoidable, reduce the nirogacestat dose per labeling and monitor for diarrhea and liver tests.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Aprepitant 的其他交互作用
Nirogacestat 的其他交互作用
常見問題
Can I take Aprepitant with Nirogacestat?
MediHelp rates the interaction as major. Aprepitant and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant may increase nirogacestat exposure by inhibiting CYP3A4. This could worsen adverse effects such as diarrhea, ovarian toxicity, hepatotoxicity and electrolyte disturbances.
How serious is the interaction between Aprepitant and Nirogacestat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid moderate CYP3A inhibitors and use an alternative antiemetic. If unavoidable, reduce the nirogacestat dose per labeling and monitor for diarrhea and liver tests.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
