藥物交互作用
Aprepitant + Pimozide
嚴重程度: 禁忌併用
Aprepitant and Pimozide: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Aprepitant inhibits CYP3A4 and slows the clearance of pimozide. Pimozide levels increase and its dose-related QT prolongation can progress to torsades de pointes.
用白話說明這項交互作用的意義
Aprepitant and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Aprepitant belongs to Gastrointestinal Tract; Pimozide belongs to Central Nervous System.
為什麼會發生
CYP3A4 inhibition increases pimozide exposure
處置方式
Do not use together; consider a different antiemetic.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Aprepitant 的其他交互作用
Pimozide 的其他交互作用
常見問題
Can I take Aprepitant with Pimozide?
MediHelp rates the interaction as contraindicated. Aprepitant and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Aprepitant inhibits CYP3A4 and slows the clearance of pimozide. Pimozide levels increase and its dose-related QT prolongation can progress to torsades de pointes.
How serious is the interaction between Aprepitant and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider a different antiemetic.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Avapritinib, Bosutinib. The full list is on the Aprepitant page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
