藥物交互作用
Aprepitant + Bosutinib
嚴重程度: 嚴重
Aprepitant and Bosutinib: major interaction.
最後更新
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摘要
Bosutinib is metabolized mainly by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme. Coadministration may raise bosutinib concentrations and increase gastrointestinal, hepatic and other toxicities.
用白話說明這項交互作用的意義
Aprepitant and Bosutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Bosutinib belongs to Oncology.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of bosutinib by aprepitant.
處置方式
Avoid moderate CYP3A4 inhibitors where possible and consider an alternative antiemetic. If used, monitor for bosutinib toxicity such as diarrhea and liver enzyme elevations, and adjust the dose as needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Aprepitant 的其他交互作用
Bosutinib 的其他交互作用
常見問題
Can I take Aprepitant with Bosutinib?
MediHelp rates the interaction as major. Aprepitant and Bosutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosutinib is metabolized mainly by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme. Coadministration may raise bosutinib concentrations and increase gastrointestinal, hepatic and other toxicities.
How serious is the interaction between Aprepitant and Bosutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid moderate CYP3A4 inhibitors where possible and consider an alternative antiemetic. If used, monitor for bosutinib toxicity such as diarrhea and liver enzyme elevations, and adjust the dose as needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
