藥物交互作用
Argatroban + Deferasirox
嚴重程度: 嚴重
Argatroban and Deferasirox: major interaction.
最後更新
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摘要
Deferasirox can cause gastrointestinal ulceration and hemorrhage, and argatroban is a direct thrombin inhibitor that impairs clotting. Together the risk of serious GI bleeding is increased.
用白話說明這項交互作用的意義
Argatroban and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Deferasirox belongs to Miscellaneous.
為什麼會發生
Additive bleeding risk: mucosal injury from deferasirox plus anticoagulation from argatroban.
處置方式
Monitor for signs of GI bleeding and hemoglobin, and monitor aPTT per argatroban protocol. Consider gastroprotection and avoid the combination in patients with prior GI ulcer or bleeding.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Deferasirox 的其他交互作用
Argatroban 的其他交互作用
常見問題
Can I take Argatroban with Deferasirox?
MediHelp rates the interaction as major. Argatroban and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox can cause gastrointestinal ulceration and hemorrhage, and argatroban is a direct thrombin inhibitor that impairs clotting. Together the risk of serious GI bleeding is increased.
How serious is the interaction between Argatroban and Deferasirox?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and hemoglobin, and monitor aPTT per argatroban protocol. Consider gastroprotection and avoid the combination in patients with prior GI ulcer or bleeding.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
