藥物交互作用
Argatroban + Defibrotide
嚴重程度: 禁忌併用
Argatroban and Defibrotide: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Defibrotide has profibrinolytic and antithrombotic activity and, combined with the direct thrombin inhibitor argatroban, may increase hemorrhage risk. Defibrotide labeling contraindicates concomitant systemic anticoagulant or fibrinolytic therapy.
用白話說明這項交互作用的意義
Argatroban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Argatroban belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.
為什麼會發生
Additive antithrombotic and profibrinolytic effects increase bleeding tendency.
處置方式
Do not use together; hold argatroban during defibrotide therapy or choose an alternative, except for routine central line maintenance.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Argatroban 的其他交互作用
Defibrotide 的其他交互作用
常見問題
Can I take Argatroban with Defibrotide?
MediHelp rates the interaction as contraindicated. Argatroban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity and, combined with the direct thrombin inhibitor argatroban, may increase hemorrhage risk. Defibrotide labeling contraindicates concomitant systemic anticoagulant or fibrinolytic therapy.
How serious is the interaction between Argatroban and Defibrotide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; hold argatroban during defibrotide therapy or choose an alternative, except for routine central line maintenance.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Ketorolac, Mifepristone, Abciximab. The full list is on the Argatroban page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
