藥物交互作用
Armodafinil + Pretomanid
嚴重程度: 嚴重
Armodafinil and Pretomanid: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Armodafinil may lower pretomanid concentrations by inducing CYP3A4. Reduced exposure could compromise the efficacy of tuberculosis regimens and promote resistance. Labeling advises avoiding strong and moderate CYP3A4 inducers.
用白話說明這項交互作用的意義
Armodafinil and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Armodafinil belongs to Central Nervous System; Pretomanid belongs to Anti Bacterial.
為什麼會發生
CYP3A4 induction by armodafinil increases the metabolism of pretomanid, a CYP3A4 substrate.
處置方式
Avoid the combination and use a non-inducing alternative to armodafinil. If unavoidable, monitor the clinical and microbiologic response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Armodafinil 的其他交互作用
Pretomanid 的其他交互作用
常見問題
Can I take Armodafinil with Pretomanid?
MediHelp rates the interaction as major. Armodafinil and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Armodafinil may lower pretomanid concentrations by inducing CYP3A4. Reduced exposure could compromise the efficacy of tuberculosis regimens and promote resistance. Labeling advises avoiding strong and moderate CYP3A4 inducers.
How serious is the interaction between Armodafinil and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative to armodafinil. If unavoidable, monitor the clinical and microbiologic response.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
