藥物交互作用
Amobarbital + Pretomanid
嚴重程度: 嚴重
Amobarbital and Pretomanid: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Amobarbital may reduce pretomanid exposure through CYP3A4 induction. Lower levels may compromise efficacy in drug-resistant tuberculosis regimens.
用白話說明這項交互作用的意義
Amobarbital and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Pretomanid belongs to Anti Bacterial.
為什麼會發生
Induction of CYP3A4 increases the metabolism of pretomanid.
處置方式
Avoid the combination and use a non-inducing alternative to amobarbital. Monitor treatment response if it cannot be avoided.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amobarbital 的其他交互作用
Pretomanid 的其他交互作用
常見問題
Can I take Amobarbital with Pretomanid?
MediHelp rates the interaction as major. Amobarbital and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital may reduce pretomanid exposure through CYP3A4 induction. Lower levels may compromise efficacy in drug-resistant tuberculosis regimens.
How serious is the interaction between Amobarbital and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative to amobarbital. Monitor treatment response if it cannot be avoided.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
