藥物交互作用
Arsenic trioxide + Sorafenib
嚴重程度: 嚴重
Arsenic trioxide and Sorafenib: major interaction.
最後更新
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摘要
Arsenic trioxide has a labeled risk of marked QT prolongation and torsades de pointes, and sorafenib may add to this effect. The combination raises the risk of serious ventricular arrhythmia.
用白話說明這項交互作用的意義
Arsenic trioxide and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Sorafenib belongs to Oncology.
為什麼會發生
Additive pharmacodynamic QT prolongation.
處置方式
Avoid the combination where possible. If it is unavoidable, check the ECG at baseline and regularly, and keep potassium above 4 mEq/L and magnesium above 1.8 mg/dL.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Sorafenib 的其他交互作用
Arsenic trioxide 的其他交互作用
常見問題
Can I take Arsenic trioxide with Sorafenib?
MediHelp rates the interaction as major. Arsenic trioxide and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide has a labeled risk of marked QT prolongation and torsades de pointes, and sorafenib may add to this effect. The combination raises the risk of serious ventricular arrhythmia.
How serious is the interaction between Arsenic trioxide and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is unavoidable, check the ECG at baseline and regularly, and keep potassium above 4 mEq/L and magnesium above 1.8 mg/dL.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
