藥物交互作用
Artemether / lumefantrine + Bosentan
嚴重程度: 嚴重
Artemether / lumefantrine and Bosentan: major interaction.
最後更新
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摘要
Bosentan is a moderate CYP3A4 inducer and may lower artemether and lumefantrine concentrations, which could cause antimalarial treatment failure. Bosentan itself is a CYP3A4 substrate and levels may be affected as well.
用白話說明這項交互作用的意義
Artemether / lumefantrine and Bosentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
CYP3A4 induction by bosentan increases the metabolism of artemether and lumefantrine.
處置方式
Avoid the combination if possible; if malaria treatment is urgent, give full-course therapy and monitor for treatment failure and follow-up parasitemia.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bosentan 的其他交互作用
常見問題
Can I take Artemether / lumefantrine with Bosentan?
MediHelp rates the interaction as major. Artemether / lumefantrine and Bosentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan is a moderate CYP3A4 inducer and may lower artemether and lumefantrine concentrations, which could cause antimalarial treatment failure. Bosentan itself is a CYP3A4 substrate and levels may be affected as well.
How serious is the interaction between Artemether / lumefantrine and Bosentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if malaria treatment is urgent, give full-course therapy and monitor for treatment failure and follow-up parasitemia.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
