藥物交互作用
Bosentan + Lonafarnib
嚴重程度: 禁忌併用
Bosentan and Lonafarnib: contraindicated interaction.
最後更新
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摘要
Lonafarnib is a sensitive CYP3A4 substrate, and bosentan as a moderate inducer may substantially reduce its exposure and effectiveness. Lonafarnib labeling contraindicates moderate and strong CYP3A inducers.
用白話說明這項交互作用的意義
Bosentan and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bosentan belongs to Miscellaneous; Lonafarnib belongs to Miscellaneous.
為什麼會發生
CYP3A4 induction by bosentan increases lonafarnib clearance.
處置方式
Do not coadminister; use an alternative to bosentan.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Bosentan 的其他交互作用
Lonafarnib 的其他交互作用
常見問題
Can I take Bosentan with Lonafarnib?
MediHelp rates the interaction as contraindicated. Bosentan and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and bosentan as a moderate inducer may substantially reduce its exposure and effectiveness. Lonafarnib labeling contraindicates moderate and strong CYP3A inducers.
How serious is the interaction between Bosentan and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative to bosentan.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
