藥物交互作用
Bosentan + Sparsentan
嚴重程度: 禁忌併用
Bosentan and Sparsentan: contraindicated interaction.
最後更新
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摘要
Sparsentan is itself a dual endothelin and angiotensin II receptor antagonist, so adding another endothelin receptor antagonist duplicates the pharmacology. This raises the risk of hypotension, syncope, hyperkalemia and deterioration of renal function, and may add to hepatotoxicity and fetal risk.
用白話說明這項交互作用的意義
Bosentan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bosentan belongs to Miscellaneous; Sparsentan belongs to Genitourinary.
為什麼會發生
Additive pharmacodynamic endothelin receptor blockade, with sparsentan also blocking the angiotensin II receptor.
處置方式
Do not combine; sparsentan labeling prohibits concomitant endothelin receptor antagonists. Choose one agent according to the indication.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Bosentan 的其他交互作用
Sparsentan 的其他交互作用
常見問題
Can I take Bosentan with Sparsentan?
MediHelp rates the interaction as contraindicated. Bosentan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is itself a dual endothelin and angiotensin II receptor antagonist, so adding another endothelin receptor antagonist duplicates the pharmacology. This raises the risk of hypotension, syncope, hyperkalemia and deterioration of renal function, and may add to hepatotoxicity and fetal risk.
How serious is the interaction between Bosentan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; sparsentan labeling prohibits concomitant endothelin receptor antagonists. Choose one agent according to the indication.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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