藥物交互作用
Artemether / lumefantrine + Carbamazepine
嚴重程度: 禁忌併用
Artemether / lumefantrine and Carbamazepine: contraindicated interaction.
最後更新
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摘要
Carbamazepine, a strong CYP3A4 inducer, can markedly lower artemether and lumefantrine concentrations. This may cause antimalarial treatment failure. Labeling contraindicates use of strong inducers.
用白話說明這項交互作用的意義
Artemether / lumefantrine and Carbamazepine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Carbamazepine induces CYP3A4, accelerating metabolism of artemether and lumefantrine.
處置方式
Avoid the combination and choose an alternative antimalarial not affected by enzyme induction. Seek specialist advice for malaria treatment.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Carbamazepine 的其他交互作用
常見問題
Can I take Artemether / lumefantrine with Carbamazepine?
MediHelp rates the interaction as contraindicated. Artemether / lumefantrine and Carbamazepine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine, a strong CYP3A4 inducer, can markedly lower artemether and lumefantrine concentrations. This may cause antimalarial treatment failure. Labeling contraindicates use of strong inducers.
How serious is the interaction between Artemether / lumefantrine and Carbamazepine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antimalarial not affected by enzyme induction. Seek specialist advice for malaria treatment.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Cabotegravir, Delamanid, Dienogest / estradiol valerate. The full list is on the Carbamazepine page.
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