藥物交互作用
Carbamazepine + Doravirine
嚴重程度: 禁忌併用
Carbamazepine and Doravirine: contraindicated interaction.
最後更新
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摘要
Carbamazepine markedly lowers doravirine concentrations through CYP3A induction, risking loss of virologic response and resistance. Labeling contraindicates strong CYP3A inducers.
用白話說明這項交互作用的意義
Carbamazepine and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Doravirine belongs to Anti Virals.
為什麼會發生
Carbamazepine induces CYP3A4, increasing doravirine clearance.
處置方式
Do not coadminister; use an alternative anticonvulsant or antiretroviral.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Carbamazepine 的其他交互作用
Doravirine 的其他交互作用
常見問題
Can I take Carbamazepine with Doravirine?
MediHelp rates the interaction as contraindicated. Carbamazepine and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine markedly lowers doravirine concentrations through CYP3A induction, risking loss of virologic response and resistance. Labeling contraindicates strong CYP3A inducers.
How serious is the interaction between Carbamazepine and Doravirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative anticonvulsant or antiretroviral.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
