藥物交互作用
Artemether / lumefantrine + Eslicarbazepine
嚴重程度: 嚴重
Artemether / lumefantrine and Eslicarbazepine: major interaction.
最後更新
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摘要
Eslicarbazepine can lower artemether and lumefantrine concentrations by inducing CYP3A4. Subtherapeutic antimalarial exposure risks treatment failure and recrudescence.
用白話說明這項交互作用的意義
Artemether / lumefantrine and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Eslicarbazepine induces CYP3A4, increasing the metabolism of artemether and lumefantrine.
處置方式
Avoid the combination when possible and use an alternative antimalarial or antiseizure drug. If it cannot be avoided, monitor closely for treatment failure and parasitological response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Eslicarbazepine 的其他交互作用
常見問題
Can I take Artemether / lumefantrine with Eslicarbazepine?
MediHelp rates the interaction as major. Artemether / lumefantrine and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eslicarbazepine can lower artemether and lumefantrine concentrations by inducing CYP3A4. Subtherapeutic antimalarial exposure risks treatment failure and recrudescence.
How serious is the interaction between Artemether / lumefantrine and Eslicarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible and use an alternative antimalarial or antiseizure drug. If it cannot be avoided, monitor closely for treatment failure and parasitological response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Avapritinib. The full list is on the Eslicarbazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
