藥物交互作用
Benzhydrocodone / acetaminophen + Eslicarbazepine
嚴重程度: 嚴重
Benzhydrocodone / acetaminophen and Eslicarbazepine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Eslicarbazepine may lower hydrocodone exposure from benzhydrocodone, reducing analgesia. Stopping eslicarbazepine later can raise hydrocodone levels and cause respiratory depression.
用白話說明這項交互作用的意義
Benzhydrocodone / acetaminophen and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
CYP3A4 induction increases hydrocodone metabolism, and withdrawal of the inducer reverses this.
處置方式
Monitor pain control and sedation, and reduce the opioid dose with close respiratory monitoring when eslicarbazepine is stopped.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Eslicarbazepine 的其他交互作用
常見問題
Can I take Benzhydrocodone / acetaminophen with Eslicarbazepine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eslicarbazepine may lower hydrocodone exposure from benzhydrocodone, reducing analgesia. Stopping eslicarbazepine later can raise hydrocodone levels and cause respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Eslicarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and sedation, and reduce the opioid dose with close respiratory monitoring when eslicarbazepine is stopped.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
