藥物交互作用
Ascorbic acid + Deferoxamine
嚴重程度: 嚴重
Ascorbic acid and Deferoxamine: major interaction.
最後更新
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摘要
Vitamin C mobilizes storage iron and makes more of it available for chelation by deferoxamine, increasing iron excretion. In iron-overloaded patients, especially with cardiac disease, high-dose vitamin C has been linked to cardiac decompensation and arrhythmia.
用白話說明這項交互作用的意義
Ascorbic acid and Deferoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Ascorbic acid increases the pool of chelatable iron, and the redox-active iron released may cause cardiac toxicity.
處置方式
Avoid ascorbic acid in patients with cardiac dysfunction on deferoxamine. If used in others, start only after deferoxamine is established, keep doses low and give it with the infusion, with cardiac monitoring.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Deferoxamine 的其他交互作用
常見問題
Can I take Ascorbic acid with Deferoxamine?
MediHelp rates the interaction as major. Ascorbic acid and Deferoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin C mobilizes storage iron and makes more of it available for chelation by deferoxamine, increasing iron excretion. In iron-overloaded patients, especially with cardiac disease, high-dose vitamin C has been linked to cardiac decompensation and arrhythmia.
How serious is the interaction between Ascorbic acid and Deferoxamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ascorbic acid in patients with cardiac dysfunction on deferoxamine. If used in others, start only after deferoxamine is established, keep doses low and give it with the infusion, with cardiac monitoring.
What other medicines interact with Deferoxamine?
MediHelp also lists interactions of Deferoxamine with, for example, Betibeglogene autotemcel, Exagamglogene autotemcel, Lovotibeglogene autotemcel. The full list is on the Deferoxamine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
