藥物交互作用
Deferoxamine + Vitamin c
嚴重程度: 嚴重
Deferoxamine and Vitamin c: major interaction.
最後更新
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摘要
Vitamin C increases the amount of iron available for chelation by deferoxamine and can raise urinary iron excretion. In iron-overloaded patients, especially those with cardiac involvement, high-dose vitamin C has been linked to cardiac dysfunction, which can be serious.
用白話說明這項交互作用的意義
Deferoxamine and Vitamin c can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferoxamine belongs to Miscellaneous; Vitamin c belongs to Gastrointestinal Tract.
為什麼會發生
Ascorbic acid mobilizes tissue iron into a labile pool, which may increase iron-mediated myocardial toxicity while enhancing deferoxamine chelation.
處置方式
Avoid vitamin C in patients with cardiac dysfunction receiving deferoxamine. If it is used, start it only after a month of regular chelation, keep doses low, and monitor cardiac function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Vitamin c 的其他交互作用
Deferoxamine 的其他交互作用
常見問題
Can I take Deferoxamine with Vitamin c?
MediHelp rates the interaction as major. Deferoxamine and Vitamin c can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin C increases the amount of iron available for chelation by deferoxamine and can raise urinary iron excretion. In iron-overloaded patients, especially those with cardiac involvement, high-dose vitamin C has been linked to cardiac dysfunction, which can be serious.
How serious is the interaction between Deferoxamine and Vitamin c?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vitamin C in patients with cardiac dysfunction receiving deferoxamine. If it is used, start it only after a month of regular chelation, keep doses low, and monitor cardiac function.
What other medicines interact with Vitamin c?
MediHelp also lists interactions of Vitamin c with, for example, Aluminum hydroxide, Dextroamphetamine transdermal, Aspirin / citric acid / sodium bicarbonate. The full list is on the Vitamin c page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
