藥物交互作用
Asenapine + Zuranolone
嚴重程度: 嚴重
Asenapine and Zuranolone: major interaction.
最後更新
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摘要
Zuranolone is a neuroactive steroid with marked CNS depressant effects, and asenapine is also sedating. Combined use can increase somnolence and impair driving and psychomotor performance.
用白話說明這項交互作用的意義
Asenapine and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
為什麼會發生
Additive CNS depression: GABA-A positive modulation plus antipsychotic sedation.
處置方式
Consider reducing the zuranolone dose and counsel on avoiding driving for at least 12 hours after dosing. Monitor for excessive sedation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Asenapine 的其他交互作用
Zuranolone 的其他交互作用
常見問題
Can I take Asenapine with Zuranolone?
MediHelp rates the interaction as major. Asenapine and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone is a neuroactive steroid with marked CNS depressant effects, and asenapine is also sedating. Combined use can increase somnolence and impair driving and psychomotor performance.
How serious is the interaction between Asenapine and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose and counsel on avoiding driving for at least 12 hours after dosing. Monitor for excessive sedation.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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