藥品參考
Zuranolone
Zuranolone is a medicine in the class central nervous system. It is used for depression.
- 藥物類別: Central Nervous System
- 用途: depression
最後更新 來源: US FDA label
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Central Nervous System
- 常見劑型
- 膠囊
- 已知交互作用
- 147 (嚴重: 52 · 中度: 93 · 輕微: 2)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
Neuroactive steroid GABA A receptor positive modulator; its mechanism in postpartum depression is not fully understood but is thought to be related to positive allosteric modulation of GABA A receptors.
成人常用劑量（仿單摘要）
Postpartum depression: 50 mg orally once daily in the evening for 14 days, with fat-containing food; consider reducing to 40 mg once daily if CNS depressant effects occur; can be used alone or as adjunct to oral antidepressants
懷孕與哺乳
- 懷孕
- Unsafe May cause fetal harm based on animal studies; human data are insufficient. Pregnancy exposure registry exists.
- 哺乳
- Unknown Present in human milk at low levels; relative infant dose <1%. No data on effects on breastfed infant. Weigh benefits of breastfeeding against maternal need.
已通報的副作用
- Somnolence
- Dizziness
- Diarrhea
- Fatigue
- Nasopharyngitis
- Urinary tract infection
黑框警語
- Causes driving impairment due to CNS depressant effects. Patients should not drive or engage in other potentially hazardous activities until at least 12 hours after administration for the duration of the 14-day course. Patients may not be able to assess their own driving competence or degree of impairment.
哪些人需要特別留意
- CNS depressant effects such as somnolence and confusion; higher risk of falls; consider dose reduction or discontinuation.
- Suicidal thoughts and behavior: consider changing regimen, including discontinuing, if depression worsens or suicidality emerges.
- Embryo-fetal toxicity: may cause fetal harm; use effective contraception during treatment and for 1 week after the final dose.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (147)
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
- Carbamazepine + Zuranolone Major
- Carisoprodol + Zuranolone Major
- Chloral hydrate + Zuranolone Major
- Chlordiazepoxide + Zuranolone Major
常見問題
What is Zuranolone used for?
Zuranolone is a medicine in the class central nervous system. It is used for Depression.
What side effects have been reported with Zuranolone?
Somnolence, Dizziness, Diarrhea, Fatigue, Nasopharyngitis, Urinary tract infection. Serious warning: Causes driving impairment due to CNS depressant effects.
Can Zuranolone be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm based on animal studies; human data are insufficient. Pregnancy exposure registry exists. Breastfeeding: Unknown. Present in human milk at low levels; relative infant dose <1%. No data on effects on breastfed infant. Weigh benefits of breastfeeding against maternal need.
What does Zuranolone interact with?
MediHelp lists 147 known interactions for Zuranolone. Major: 52 · Moderate: 93 · Minor: 2. The most serious include Alprazolam, Amobarbital, Apalutamide.
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