藥物交互作用
Butorphanol + Zuranolone
嚴重程度: 嚴重
Butorphanol and Zuranolone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired driving ability. Taken with butorphanol, CNS depression and psychomotor impairment may be greater.
用白話說明這項交互作用的意義
Butorphanol and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Butorphanol belongs to Musculoskeletal; Zuranolone belongs to Central Nervous System.
為什麼會發生
Additive pharmacodynamic CNS depression via GABA-A modulation and opioid receptor agonism.
處置方式
Avoid if possible; if both are needed, consider lowering the dose of zuranolone or butorphanol. Monitor sedation and respiratory function and counsel against driving.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Butorphanol 的其他交互作用
Zuranolone 的其他交互作用
常見問題
Can I take Butorphanol with Zuranolone?
MediHelp rates the interaction as major. Butorphanol and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired driving ability. Taken with butorphanol, CNS depression and psychomotor impairment may be greater.
How serious is the interaction between Butorphanol and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are needed, consider lowering the dose of zuranolone or butorphanol. Monitor sedation and respiratory function and counsel against driving.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
