藥物交互作用
Atazanavir + Darifenacin
嚴重程度: 嚴重
Atazanavir and Darifenacin: major interaction.
最後更新
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摘要
Atazanavir is a strong CYP3A4 inhibitor and can substantially raise darifenacin exposure. This increases the risk of anticholinergic effects such as dry mouth, constipation, urinary retention and QT-related concerns at high concentrations.
用白話說明這項交互作用的意義
Atazanavir and Darifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Darifenacin belongs to Genitourinary.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of darifenacin.
處置方式
Limit darifenacin to 7.5 mg daily with strong CYP3A4 inhibitors and monitor for anticholinergic adverse effects, or choose an alternative.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Darifenacin 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Darifenacin?
MediHelp rates the interaction as major. Atazanavir and Darifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and can substantially raise darifenacin exposure. This increases the risk of anticholinergic effects such as dry mouth, constipation, urinary retention and QT-related concerns at high concentrations.
How serious is the interaction between Atazanavir and Darifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit darifenacin to 7.5 mg daily with strong CYP3A4 inhibitors and monitor for anticholinergic adverse effects, or choose an alternative.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Bethanechol, Clarithromycin, Clozapine. The full list is on the Darifenacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
