藥物交互作用
Darifenacin + Darunavir
嚴重程度: 嚴重
Darifenacin and Darunavir: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Darunavir, usually given with a booster such as ritonavir or cobicistat, strongly inhibits CYP3A4 and can substantially raise darifenacin levels. This increases the risk of anticholinergic toxicity.
用白話說明這項交互作用的意義
Darifenacin and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darifenacin belongs to Genitourinary; Darunavir belongs to Anti Virals.
為什麼會發生
Inhibition of CYP3A4 by boosted darunavir reduces darifenacin clearance.
處置方式
Do not exceed darifenacin 7.5 mg daily and monitor for anticholinergic toxicity. Consider an alternative bladder agent.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Darifenacin 的其他交互作用
Darunavir 的其他交互作用
常見問題
Can I take Darifenacin with Darunavir?
MediHelp rates the interaction as major. Darifenacin and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually given with a booster such as ritonavir or cobicistat, strongly inhibits CYP3A4 and can substantially raise darifenacin levels. This increases the risk of anticholinergic toxicity.
How serious is the interaction between Darifenacin and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed darifenacin 7.5 mg daily and monitor for anticholinergic toxicity. Consider an alternative bladder agent.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
