藥物交互作用
Atenolol-chlorthalidone + Timolol
嚴重程度: 嚴重
Atenolol-chlorthalidone and Timolol: major interaction.
最後更新 來源: US FDA label
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摘要
Atenolol and timolol are both beta-blockers, so combining them is duplication. This increases bradycardia, hypotension and AV block risk without added benefit.
用白話說明這項交互作用的意義
Atenolol-chlorthalidone and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol-chlorthalidone belongs to Cardiovascular; Timolol belongs to Cardiovascular.
為什麼會發生
Additive beta-adrenergic receptor blockade (therapeutic duplication).
處置方式
Avoid combining; use one beta-blocker. If timolol is an eye drop, monitor heart rate as systemic absorption can add to atenolol effects.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Atenolol-chlorthalidone 的其他交互作用
Timolol 的其他交互作用
常見問題
Can I take Atenolol-chlorthalidone with Timolol?
MediHelp rates the interaction as major. Atenolol-chlorthalidone and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atenolol and timolol are both beta-blockers, so combining them is duplication. This increases bradycardia, hypotension and AV block risk without added benefit.
How serious is the interaction between Atenolol-chlorthalidone and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use one beta-blocker. If timolol is an eye drop, monitor heart rate as systemic absorption can add to atenolol effects.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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