藥物交互作用
Amiodarone + Timolol
嚴重程度: 嚴重
Amiodarone and Timolol: major interaction.
最後更新
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摘要
Amiodarone can cause bradycardia and AV block, and combined with timolol the risk of severe bradycardia, conduction disturbance or cardiac arrest increases. Amiodarone may also raise timolol levels through CYP2D6 inhibition, including with ophthalmic timolol.
用白話說明這項交互作用的意義
Amiodarone and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Timolol belongs to Cardiovascular.
為什麼會發生
Additive negative chronotropic and dromotropic effects, plus CYP2D6 inhibition by amiodarone reducing timolol clearance.
處置方式
Monitor heart rate and ECG, and reduce the timolol dose or avoid the combination in patients with conduction disease or low baseline heart rate.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Timolol 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Timolol?
MediHelp rates the interaction as major. Amiodarone and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone can cause bradycardia and AV block, and combined with timolol the risk of severe bradycardia, conduction disturbance or cardiac arrest increases. Amiodarone may also raise timolol levels through CYP2D6 inhibition, including with ophthalmic timolol.
How serious is the interaction between Amiodarone and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, and reduce the timolol dose or avoid the combination in patients with conduction disease or low baseline heart rate.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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