藥物交互作用
Atorvastatin + Danazol
嚴重程度: 嚴重
Atorvastatin and Danazol: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Danazol inhibits CYP3A4 and may increase atorvastatin levels. Raised statin exposure increases the likelihood of myopathy and rhabdomyolysis.
用白話說明這項交互作用的意義
Atorvastatin and Danazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Danazol inhibits CYP3A4-mediated metabolism of atorvastatin.
處置方式
Use the lowest effective atorvastatin dose and counsel patients to report muscle symptoms; check CK if symptoms occur. Consider an alternative statin less reliant on CYP3A4, such as rosuvastatin or pravastatin.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atorvastatin 的其他交互作用
常見問題
Can I take Atorvastatin with Danazol?
MediHelp rates the interaction as major. Atorvastatin and Danazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Danazol inhibits CYP3A4 and may increase atorvastatin levels. Raised statin exposure increases the likelihood of myopathy and rhabdomyolysis.
How serious is the interaction between Atorvastatin and Danazol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atorvastatin dose and counsel patients to report muscle symptoms; check CK if symptoms occur. Consider an alternative statin less reliant on CYP3A4, such as rosuvastatin or pravastatin.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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