藥物交互作用
Atorvastatin + Tipranavir
嚴重程度: 禁忌併用
Atorvastatin and Tipranavir: contraindicated interaction.
最後更新
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摘要
Ritonavir-boosted tipranavir inhibits CYP3A4 and markedly raises atorvastatin exposure. This increases the risk of myopathy and rhabdomyolysis, and labeling advises against the combination.
用白話說明這項交互作用的意義
Atorvastatin and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atorvastatin belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
為什麼會發生
Inhibition of CYP3A4-mediated atorvastatin metabolism by ritonavir-boosted tipranavir.
處置方式
Avoid atorvastatin with tipranavir/ritonavir; use an alternative statin such as pravastatin or rosuvastatin with dose limits. Monitor for muscle symptoms if any statin is used.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Atorvastatin 的其他交互作用
Tipranavir 的其他交互作用
常見問題
Can I take Atorvastatin with Tipranavir?
MediHelp rates the interaction as contraindicated. Atorvastatin and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir-boosted tipranavir inhibits CYP3A4 and markedly raises atorvastatin exposure. This increases the risk of myopathy and rhabdomyolysis, and labeling advises against the combination.
How serious is the interaction between Atorvastatin and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid atorvastatin with tipranavir/ritonavir; use an alternative statin such as pravastatin or rosuvastatin with dose limits. Monitor for muscle symptoms if any statin is used.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Atorvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
