藥物交互作用
Atorvastatin + Clarithromycin
嚴重程度: 嚴重
Atorvastatin and Clarithromycin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Clarithromycin markedly increases atorvastatin exposure. This raises the risk of myopathy and rhabdomyolysis.
用白話說明這項交互作用的意義
Atorvastatin and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atorvastatin belongs to Cardiovascular; Clarithromycin belongs to Anti Bacterial.
為什麼會發生
Inhibition of CYP3A4, and also P-glycoprotein and OATP1B1 transport, by clarithromycin reduces atorvastatin clearance.
處置方式
Limit atorvastatin to 20 mg daily per labeling or hold it during the clarithromycin course. Counsel the patient to report muscle pain or weakness.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clarithromycin 的其他交互作用
Atorvastatin 的其他交互作用
常見問題
Can I take Atorvastatin with Clarithromycin?
MediHelp rates the interaction as major. Atorvastatin and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin markedly increases atorvastatin exposure. This raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Atorvastatin and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atorvastatin to 20 mg daily per labeling or hold it during the clarithromycin course. Counsel the patient to report muscle pain or weakness.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
