藥物交互作用
Avanafil + Conivaptan
嚴重程度: 禁忌併用
Avanafil and Conivaptan: contraindicated interaction.
最後更新
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摘要
Conivaptan is a strong CYP3A4 inhibitor and can markedly raise avanafil levels. Excess PDE5 inhibition may cause severe hypotension, syncope, visual changes and priapism.
用白話說明這項交互作用的意義
Avanafil and Conivaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
CYP3A4 inhibition by conivaptan decreases avanafil clearance.
處置方式
Avoid avanafil during conivaptan therapy. Use an alternative erectile dysfunction treatment if needed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Avanafil 的其他交互作用
常見問題
Can I take Avanafil with Conivaptan?
MediHelp rates the interaction as contraindicated. Avanafil and Conivaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a strong CYP3A4 inhibitor and can markedly raise avanafil levels. Excess PDE5 inhibition may cause severe hypotension, syncope, visual changes and priapism.
How serious is the interaction between Avanafil and Conivaptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid avanafil during conivaptan therapy. Use an alternative erectile dysfunction treatment if needed.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
