藥物交互作用
Axitinib + Dicloxacillin
嚴重程度: 中度
Axitinib and Dicloxacillin: moderate interaction.
最後更新
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摘要
Dicloxacillin is a weak inducer of CYP3A4 and may lower axitinib exposure, which is mainly cleared by CYP3A4/5. Reduced axitinib levels could diminish antitumour efficacy. The clinical effect is probably modest.
用白話說明這項交互作用的意義
Axitinib and Dicloxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Dicloxacillin belongs to Anti Bacterial.
為什麼會發生
Dicloxacillin induces CYP3A4, increasing the metabolism of axitinib.
處置方式
Monitor for reduced axitinib response when dicloxacillin is given for more than a short course. Use a non-inducing antibiotic if one is suitable.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dicloxacillin 的其他交互作用
Axitinib 的其他交互作用
常見問題
Can I take Axitinib with Dicloxacillin?
MediHelp rates the interaction as moderate. Axitinib and Dicloxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicloxacillin is a weak inducer of CYP3A4 and may lower axitinib exposure, which is mainly cleared by CYP3A4/5. Reduced axitinib levels could diminish antitumour efficacy. The clinical effect is probably modest.
How serious is the interaction between Axitinib and Dicloxacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced axitinib response when dicloxacillin is given for more than a short course. Use a non-inducing antibiotic if one is suitable.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Bcg vaccine live. The full list is on the Dicloxacillin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
