藥物交互作用
Apalutamide + Axitinib
嚴重程度: 嚴重
Apalutamide and Axitinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Apalutamide, a strong CYP3A4 inducer, can markedly reduce axitinib exposure and compromise anticancer efficacy.
用白話說明這項交互作用的意義
Apalutamide and Axitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Axitinib belongs to Oncology.
為什麼會發生
Induction of CYP3A4/5 increases axitinib metabolism.
處置方式
Avoid strong CYP3A4 inducers with axitinib and choose an alternative. If unavoidable, monitor efficacy closely and adjust the axitinib dose per labeling.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Apalutamide 的其他交互作用
Axitinib 的其他交互作用
常見問題
Can I take Apalutamide with Axitinib?
MediHelp rates the interaction as major. Apalutamide and Axitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide, a strong CYP3A4 inducer, can markedly reduce axitinib exposure and compromise anticancer efficacy.
How serious is the interaction between Apalutamide and Axitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inducers with axitinib and choose an alternative. If unavoidable, monitor efficacy closely and adjust the axitinib dose per labeling.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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