藥物交互作用
Azathioprine + Mycophenolic acid
嚴重程度: 嚴重
Azathioprine and Mycophenolic acid: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both inhibit purine synthesis pathways and together can cause additive bone marrow suppression, with leukopenia and increased infection risk. Combination offers no established benefit.
用白話說明這項交互作用的意義
Azathioprine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Mycophenolic acid belongs to Miscellaneous.
為什麼會發生
Additive inhibition of purine metabolism in lymphocytes and marrow cells.
處置方式
Avoid the combination; use one agent only. If a switch is made, monitor complete blood counts.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Mycophenolic acid 的其他交互作用
Azathioprine 的其他交互作用
常見問題
Can I take Azathioprine with Mycophenolic acid?
MediHelp rates the interaction as major. Azathioprine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both inhibit purine synthesis pathways and together can cause additive bone marrow suppression, with leukopenia and increased infection risk. Combination offers no established benefit.
How serious is the interaction between Azathioprine and Mycophenolic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use one agent only. If a switch is made, monitor complete blood counts.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Cholestyramine, Ganciclovir. The full list is on the Mycophenolic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
