藥物交互作用
Cholestyramine + Mycophenolic acid
嚴重程度: 嚴重
Cholestyramine and Mycophenolic acid: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cholestyramine binds mycophenolic acid and interrupts its enterohepatic recirculation, substantially lowering exposure. This may cause loss of immunosuppressive effect and graft rejection.
用白話說明這項交互作用的意義
Cholestyramine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholestyramine belongs to Cardiovascular; Mycophenolic acid belongs to Miscellaneous.
為什麼會發生
Bile acid sequestrant binds mycophenolate glucuronide and MPA in the gut, preventing reabsorption.
處置方式
Avoid coadministration; use an alternative lipid-lowering agent. If unavoidable, monitor for rejection and consider MPA exposure monitoring.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Mycophenolic acid 的其他交互作用
Cholestyramine 的其他交互作用
常見問題
Can I take Cholestyramine with Mycophenolic acid?
MediHelp rates the interaction as major. Cholestyramine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cholestyramine binds mycophenolic acid and interrupts its enterohepatic recirculation, substantially lowering exposure. This may cause loss of immunosuppressive effect and graft rejection.
How serious is the interaction between Cholestyramine and Mycophenolic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; use an alternative lipid-lowering agent. If unavoidable, monitor for rejection and consider MPA exposure monitoring.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Ganciclovir. The full list is on the Mycophenolic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
