藥物交互作用
Azilsartan-chlorthalidone + Calcifediol
嚴重程度: 中度
Azilsartan-chlorthalidone and Calcifediol: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Chlorthalidone lowers urinary calcium excretion, and calcifediol, a vitamin D metabolite, increases calcium absorption. Together they can produce hypercalcemia, particularly with high vitamin D doses, calcium supplements or reduced renal function.
用白話說明這項交互作用的意義
Azilsartan-chlorthalidone and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Calcifediol belongs to Musculoskeletal.
為什麼會發生
Thiazide-enhanced distal tubular calcium reabsorption combined with vitamin D-driven intestinal calcium absorption.
處置方式
Monitor serum calcium and renal function periodically, especially after dose changes. Reduce the vitamin D or calcium dose if hypercalcemia develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Azilsartan-chlorthalidone 的其他交互作用
Calcifediol 的其他交互作用
常見問題
Can I take Azilsartan-chlorthalidone with Calcifediol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone lowers urinary calcium excretion, and calcifediol, a vitamin D metabolite, increases calcium absorption. Together they can produce hypercalcemia, particularly with high vitamin D doses, calcium supplements or reduced renal function.
How serious is the interaction between Azilsartan-chlorthalidone and Calcifediol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically, especially after dose changes. Reduce the vitamin D or calcium dose if hypercalcemia develops.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
