Drug interactions
Azilsartan-chlorthalidone + Calcifediol
Severity: Moderate
Azilsartan-chlorthalidone and Calcifediol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone lowers urinary calcium excretion, and calcifediol, a vitamin D metabolite, increases calcium absorption. Together they can produce hypercalcemia, particularly with high vitamin D doses, calcium supplements or reduced renal function.
What this interaction means in plain words
Azilsartan-chlorthalidone and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Calcifediol belongs to Musculoskeletal.
Why it happens
Thiazide-enhanced distal tubular calcium reabsorption combined with vitamin D-driven intestinal calcium absorption.
What to do
Monitor serum calcium and renal function periodically, especially after dose changes. Reduce the vitamin D or calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
- Calcifediol + Captopril-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Calcifediol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone lowers urinary calcium excretion, and calcifediol, a vitamin D metabolite, increases calcium absorption. Together they can produce hypercalcemia, particularly with high vitamin D doses, calcium supplements or reduced renal function.
How serious is the interaction between Azilsartan-chlorthalidone and Calcifediol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically, especially after dose changes. Reduce the vitamin D or calcium dose if hypercalcemia develops.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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