藥物交互作用
Amobarbital + Calcifediol
嚴重程度: 中度
Amobarbital and Calcifediol: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Barbiturates can accelerate vitamin D metabolism and lower circulating calcifediol, and long-term use is associated with reduced bone mineral density and osteomalacia.
用白話說明這項交互作用的意義
Amobarbital and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Calcifediol belongs to Musculoskeletal.
為什麼會發生
Induction of hepatic CYP enzymes (including CYP3A4) increases catabolism of vitamin D metabolites.
處置方式
Monitor serum 25-hydroxyvitamin D, calcium and parathyroid hormone and increase the vitamin D dose if levels fall. Reassess bone health during prolonged barbiturate therapy.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amobarbital 的其他交互作用
Calcifediol 的其他交互作用
常見問題
Can I take Amobarbital with Calcifediol?
MediHelp rates the interaction as moderate. Amobarbital and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can accelerate vitamin D metabolism and lower circulating calcifediol, and long-term use is associated with reduced bone mineral density and osteomalacia.
How serious is the interaction between Amobarbital and Calcifediol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum 25-hydroxyvitamin D, calcium and parathyroid hormone and increase the vitamin D dose if levels fall. Reassess bone health during prolonged barbiturate therapy.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
